How does the prevalence of PSC in UC compare between North American and European cohorts

the evidence does not directly compare North American and European PSC prevalence within ulcerative colitis cohorts, but it reports that about 3–8% of UC patients have PSC overall ¹, with a Swedish population-based UC cohort finding 3.7% ² and a regional European UC cohort finding 3.6% ³. general PSC prevalence in the population is reported as similar between North America and Europe, ranging 6–16 cases per 100,000 inhabitants, with incidence appearing comparable in North American and Northern European countries ⁴. ^1–4

What is known: - About 3–8% of ulcerative colitis patients are reported to have PSC, and 60–80% of European and US PSC patients have associated IBD. ¹ - A Swedish population-based UC cohort found PSC in 3.7% of patients, rising to 5.5% in those with substantial colitis. ² - A European regional UC cohort found PSC in 3.6% of patients. ³ - Population PSC prevalence is 6–16 per 100,000 in North America and Europe, with incidence appearing similar between North American and Northern European countries. ⁴

What is unknown / caveats: - No excerpt directly compares PSC prevalence in UC cohorts between North America and Europe - Cited UC-cohort prevalence figures come from European (Swedish/regional) populations, without a matched North American UC prevalence figure to compare - The excerpts speak to overall PSC prevalence and to population-level incidence similarity, not to a direct continental comparison confined to UC cohorts.

## References

1. Tanaka A, Mertens JC. Ulcerative Colitis with and without Primary Sclerosing Cholangitis: Two Different Diseases?. Inflamm Intest Dis. 2016. PMID: 29922654.

2. Olsson R, Danielsson A, Järnerot G, Lindström E, Lööf L, Rolny P, Rydén BO, Tysk C, Wallerstedt S. Prevalence of primary sclerosing cholangitis in patients with ulcerative colitis. Gastroenterology. 1991. PMID: 2013375.

3. Rasmussen HH, Fallingborg JF, Mortensen PB, Freund LG, Tage-Jensen U, Kruse V, Rasmussen SN. [Sclerosing cholangitis and ulcerative colitis. Regional prevalence]. Ugeskr Laeger. 1994. PMID: 8296407.

4. Eaton JE, Talwalkar JA, Lazaridis KN, Gores GJ, Lindor KD. Pathogenesis of primary sclerosing cholangitis and advances in diagnosis and management. Gastroenterology. 2013. PMID: 23827861.

For educational use only, not a substitute for clinical judgement or medical advice. Consult qualified clinicians for diagnosis and treatment decisions. This tool may contain errors; use the flag button below to report inaccurate or harmful content.

---

_Draft, generated by the IBDology RAG and not yet clinician-reviewed. Answers are grounded in the retrieved literature listed above; a high faithfulness score means the answer matches its sources, not that the sources are correct._