What is the incidence of VTE in paediatric-onset IBD

What is known

- Cerebral sinus venous thrombosis was the most frequently reported VTE type (50% of cases). ¹ - All but one of the 20 patients had active IBD; 45% were using steroids and 45% were hospitalized, and none had received thromboprophylaxis. ¹ - For context, general paediatric population-based studies report annual VTE incidences of 0.07–0.49 per 10,000 children, rising to 19–58 per 10,000 admissions in hospitalized children. ¹

What is unknown / caveats

- Single primary incidence estimate based on only 20 VTE cases, giving a wide confidence interval - The second retrieved source is a scoping review whose retrieved excerpt does not report an incidence figure - The estimate rests on a small number of events, so the precise incidence remains uncertain.

## References

1. Aardoom MA, Klomberg RCW, Kemos P, Ruemmele FM, PIBD-VTE G, van Ommen CHH, de Ridder L, Croft NM, PIBD-SETQuality C. The Incidence and Characteristics of Venous Thromboembolisms in Paediatric-Onset Inflammatory Bowel Disease: A Prospective International Cohort Study Based on the PIBD-SETQuality Safety Registry. J Crohns Colitis. 2022. PMID: 34599822.

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_Draft, generated by the IBDology RAG and not yet clinician-reviewed. Answers are grounded in the retrieved literature listed above; a high faithfulness score means the answer matches its sources, not that the sources are correct._